Loss of NADPH-diaphorase containing neurones after reversible focal ischaemia in rats delayed by L-NAME
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چکیده
منابع مشابه
Vulnerability of cultured cortical neurons to damage by excitotoxins: differential susceptibility of neurons containing NADPH-diaphorase.
Quantitative concentration-toxicity relationships were determined for the injury of cultured murine cortical neurons by several excitatory amino acid (EAA) agonists. All tested agonists produced concentration-dependent neuronal injury at concentrations between 1 and 1000 microM. With 5 min exposure, glutamate, aspartate, N-methyl-D-aspartate (NMDA), L-homocysteate (HCA), and quisqualate all had...
متن کاملInnervation of the sheep pineal gland by nonsympathetic nerve fibers containing NADPH-diaphorase activity.
We used the NADPH-diaphorase histochemical method as a potential marker for nitric oxide synthase (NOS)-containing nerve fibers innervating the pineal gland of the sheep. Nerve fibers containing NADPH-diaphorase activity provide dense innervation of the sheep pineal gland. The nerve fibers were located in the pineal capsule, in the connective tissue septae separating the lobull of the gland, an...
متن کاملL-NAME and 7-Nitroindazole Reduces Brain Injuries in Transient Focal Cerebral Ischemia in Rat
Background: The role of nitric oxide (NO) of endothelial or neuronal origins in cerebral ischemia and reperfusion injuries are far from being settled, extending from being important to not having any role at all. Objective: To investigate the role of NO of endothelial and neuronal origins in ischemia/reperfusion injuries in focal cerebral ischemia, L-NAME, a non selective NO synthase inhibitor...
متن کاملNicotinomid Adenin Dinucleotide Phosphate-Diaphorase (NADPH-d) Activity and CB-28 kDa Immunoreactivity in Spinal Neurons of Neonatal Rats after a Peripheral Nerve Lesion
Our previous studies have shown that median and ulnar nerve lesion induced calbindin (CB) immunoreactivity in some injured motoneurons in developing rats. Motoneuron death induced by sciatic nerve transection in neonatal rats has been related to induction of neuronal isoform of nitric oxide synthase (nNOS). The present study investigated whether expression of CB and nicotinomid adenin dinucleot...
متن کاملPermanent and transitory morphometric changes of NADPH-diaphorase-containing neurons in the rat visual cortex after early malnutrition.
We investigated the histochemical positivity to NADPH-diaphorase, which reveals nitric oxide synthase activity, in area 17 of rats malnourished early in life, both in the post-weaning period (group M1), and in adulthood after nutritional recovering (group M2). Control pups (C1 and C2 groups) received ad libitum after weaning the same diets as their mothers. Rats of group M2 were nutritionally r...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1995
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1995.tb15076.x